STRESS TEST “DOUBLE LOCAL HYPOXIA OF THE UPPER EXTREMITY” AND THE RISK OF THROMBO-HEMORRHAGIC COMPLICATIONS AT THE PERIOPERATIVE STAGE

Abstract

Introduction. Prothrombotic is a condition that leads to the development of venous or arterial thrombosis and its consequences. Arterial thrombosis takes a leading position among thrombotic complications and, as a rule, leads to severe disability and mortality. Acute coronary syndrome and acute cerebrovascular accident are the most severe and frequent consequences of atherothrombosis. Venous thromboembolism is the most common vascular disease after acute myocardial infarction and stroke. According to a number of authors, the frequency of objectively confirmed in-hospital deep vein thrombosis (DVT) reaches approximately 10 to 40% among patients undergoing general surgery and 40 to 60% after major orthopedic operations. In 25-30% of patients, the thrombosis affects the deep veins, causing DVT and can lead to pulmonary embolism (PE). In surgical and orthopedic patients, PE occurs in 10% of patients and is the main cause of hospital deaths. There are many factors that cause a violation of the hemostatic potential in patients who have undergone surgery with existing risk factors for thromboembolism, so it is necessary to conduct a more detailed study of the blood coagulation system, including the study of the compensatory capabilities of the hemocoagulation system. One of these methods is a functional test with double local hypoxia of the upper extremity (DLGHV) under the control of thromboelastography (TEG). The purpose of the study is to identify the degree of thrombotic risk in patients who are preparing for planned surgical intervention and belong to the risk group of thrombotic complications, to compare and evaluate the state of the hemostasis system in healthy volunteers and in this cohort. patients using a functional test with double local hypoxia of the upper limb by the thromboelastography method.