BLOCKERS 5-HT3 SEROTONIN RECEPTOR IN THE COMPLEX OF INTENSIVE THERAPY OF TRAUMATIC DISEASE IN PATIENTS WITH POLYTRAUMA

Authors

  • Yu.V. Volkova
  • M.O. Dolzhenko

DOI:

https://doi.org/10.31379/2411.2616.17.1.3

Keywords:

multiple trauma, serotonin receptors, intensive therapy.

Abstract

In the investigation we performed complex clinical and laboratory examination in patients with multiple trauma. We described the role of the 3rd type serotonin receptors (5-HT3) in the pathogenesis of traumatic disease. We found a positive effect of using of 5-HT3 blockers in complex intensive therapy in patients with cranioabdominal injury.

References

Agostino, A. D., English, C. D., Jose, A. Vortioxetine (Brintellix): A New Serotonergic Antidepressant. // Drug Forecast. – Vol. 40(1). – P. 36–40.

A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: Treatment of involuntary emotional expression disorder. / L. L. Werling [et al.] // Experimental Neurology. – 2007. – P. 248–257. https://doi.org/10.1016/j.

expneurol.2007.06.013

Serotonin Receptors – From Molecular Biology to Clinical Applications. / M. Pytliak [et al.] // Physiology Research. – 2011. – Vol. 1(60). – P. 15–25.

H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs. / W. K. Kroeze [et al.] // 2007. – P. 519–526. https://doi.org/10.1038/sj.npp.1300027

Serotonin, serotonin receptors and their actions in insects. / R. Vleugels [et al.] // Neurotransmitter. – 2015. – Vol. 2(e314). – P. 1–14. https://doi.org/10.14800/nt.314

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum: an enterobone endocrine axis. / V. K. Yadav [et al.] // Cell. – 2008. – Vol. 135(5). – P. 825–837. https://doi.org/10.1016/j.cell.2008.09.059.Lrp5

Hoyer, D., Hannon, J. P., Martin, G. R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacology, Biochemistry and Behavior. – 2002. – Vol. 71. – P. 533–554.

Selective 5-HT 6 receptor ligands : Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. / D. J. Heal [et al.] // Pharmacology & Theurapeutics. – 2008. – Vol. 117. – P. 207–231. https://doi.org/10.1016/j.pharmthera.2007.08.006

Interplay between Serotonin 5-HT 1A and 5-HT 7 Receptors in Depressive Disorders Signaling Pathways, and Distribution in. / V. S. Naumenko [et al.] // CNS Neuroscience & Therapeutics. – 2004. – Vol. 20. – P. 582–590. https://doi.org/10.1111/cns.12247

Hedlund, P. B., Sutcliffe, J. G. Functional, molecular and pharmacological advances in 5-HT 7 receptor research. // Trends in Pharmacological Sciences. – 2004. – Vol. 25(9). – P. 5–10. https://doi.org/10.1016/j.tips.2004.07.002

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Published

2022-02-14

How to Cite

Volkova, Y., & Dolzhenko, M. (2022). BLOCKERS 5-HT3 SEROTONIN RECEPTOR IN THE COMPLEX OF INTENSIVE THERAPY OF TRAUMATIC DISEASE IN PATIENTS WITH POLYTRAUMA. Clinical Anesthesiology, Intensive Care and Emergency Medicine, (1), 25–31. https://doi.org/10.31379/2411.2616.17.1.3