ON THE ISSUE OF SYSTEM OF BLOOD COAGULATION AND HIS COMPLICATIONS IN PATIENTS WITH LVAD IN THE POSTOPERATIVE PERIOD
DOI:
https://doi.org/10.32782/2411-9164.19.1-8Keywords:
left ventricle assist device (LVAD), anticoagulant targeted therapy (ATT), perioperative complicationsAbstract
The work was carried out within the framework of a bilateral agreement on scientific cooperation between the department of Anesthesiology&Intensive Care in National Medical Academy of Post-Graduate Education Named After P.L. Shupik and the Silesian Center for Heart Diseases (Poland), as a final report. The purpose of this scientific work is to analyze the state of the blood coagulation system and its response to therapy and complications in the early postoperative period in fifty patients with implanted devices for mechanical support of the left ventricle, left ventricle assist device, LVAD, in the Silesian Heart Disease Center (Śląski Centrum Chorób Serca – SCCS), Poland. Patients were divided into two groups, a control group receiving classical anticoagulation targeted therapy (ATT), which included the most controlled monotherapy with heparin, after reaching the target values of APTT, the addition and transition to monotherapy with warfarin until reaching the target INR and ASA, and the main, research group, who received an alternative ATT consisting of the previous one with the addition of P2Y12- receptor blockers and Xa-factors. The result of the work demonstrated the benefit of the modified anticoagulant treatment scheme against the classical approach to reduce clinical complications with clear confirmation by correlation-regression indicators of a significant degree of reliability.
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